Serological tests play a crucial role in the diagnosis of autoimmune diseases by: 1. Detecting autoantibodies: Identifying specific antibodies against self-antigens, indicating an autoimmune response....
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The complement fixation test (CFT) is a serological test used to detect the presence of specific antibodies or antigens in a patient's serum. Here's how it's used: 1. Principle: The test is based on the...
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Control samples are used in serological assays to: 1. Validate test performance: Ensure the test is working correctly and producing accurate results. 2. Detect cross-reactivity: Identify non-specific...
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Cross-reactivity in serological testing refers to the phenomenon where an antibody reacts with an antigen other than the one it was raised against, due to similarities in their molecular structures. This...
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Direct and indirect immunoassays are laboratory techniques used to detect and measure antigens or antibodies. The main difference between them is the method of detection: Direct Immunoassay: 1. Labelled...
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Serological tests are essential in blood typing to: 1. Determine ABO blood group: Identify the presence or absence of A and B antigens on red blood cells (RBCs) using anti-A and anti-B antibodies. 2....
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Serological testing has limitations in diagnosing infectious diseases, including: 1. False negatives: Early infection, immune suppression, or poor immune response can lead to false-negative results....
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Serological tests play a crucial role in monitoring the progression of chronic infections by: 1. Tracking antibody levels: Measuring changes in antibody titers over time helps assess the immune response...
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Agglutination tests play a significant role in serology as they help detect and identify antibodies or antigens in a patient's serum. Here's how: 1. Antibody detection: Agglutination tests detect the...
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The key differences between primary and secondary immune responses detectable by serology are: Primary Immune Response: 1. Slow onset: Takes 7-10 days to develop 2. Low antibody titer: Initial antibody...
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