Which anti diabetic drug can increase the risk bone fracture?
The anti-diabetic drug that can increase the risk of bone fracture is:
Thiazolidinediones (TZDs), specifically:
– Rosiglitazone (Avandia)
– Pioglitazone (Actos)
TZDs are a class of medications that improve insulin sensitivity and are used to treat type 2 diabetes. However, they have been linked to an increased risk of osteoporosis and bone fractures, particularly in older adults.
The exact mechanism is not fully understood, but it’s thought that TZDs may:
– Decrease bone formation
– Increase bone resorption
– Affect bone cell function
Other anti-diabetic medications, such as metformin, sulfonylureas, and DPP-4 inhibitors, do not have a significant association with increased bone fracture risk.
It’s essential to discuss any concerns with your healthcare provider, as they can help you weigh the benefits and risks of your medications and monitor your bone health.