What role do genetic factors play in the development of atopic dermatitis?

Genetic factors play a significant role in the development of atopic dermatitis. Individuals with a family history of atopic conditions, such as asthma or hay fever, are at higher risk of developing the condition. Genetic mutations, particularly in genes related to skin barrier function (like the FLG gene), can impair the skin’s ability to retain moisture and protect against irritants and allergens, increasing susceptibility to atopic dermatitis.