Which of the following is characteristic of primary myelofibrosis?
A) Auer rods
B) Leukoerythroblastosis
C) BCR-ABL gene
D) JAK2 V617F mutation
aanya.bansal Answered question August 31, 2024
The correct answer is D) JAK2 V617F mutation.
Primary myelofibrosis (PMF) is a type of myeloproliferative neoplasm (MPN) characterized by:
– Bone marrow fibrosis (scarring)
– Abnormal blood cell production
– Splenomegaly (enlarged spleen)
The JAK2 V617F mutation is a common genetic finding in PMF, occurring in approximately 50-60% of cases. This mutation leads to the activation of the JAK2 signaling pathway, promoting abnormal blood cell growth and fibrosis.
aanya.bansal Answered question August 31, 2024