Monocytes
A. Originate from precursor cells in lymph nodes.
B. Can increase in number when their parent cells are stimulated by factors released from activated lymphocytes.
C. Unlike granulocytes, do not migrate across capillary walls.
D. Can transform into large multinucleated cells in certain chronic infections.
E. Manufacture immunoglobulin M.
A. Originate from precursor cells in lymph nodes** is incorrect. Monocytes originate from precursor cells in the bone marrow, not the lymph nodes. The other statements are correct: monocytes can increase in number due to stimulation by factors from activated lymphocytes, do migrate across capillary walls, can transform into large multinucleated cells in certain chronic infections, and do not manufacture immunoglobulin M (which is produced by B cells).