Which form of leukemia is most associated with the t(9;22) translocation?
- A) Acute lymphoblastic leukemia (ALL)
- B) Acute myeloid leukemia (AML)
- C) Chronic lymphocytic leukemia (CLL)
- D) Chronic myeloid leukemia (CML)
The correct answer is D) Chronic myeloid leukemia (CML).
The t(9;22) translocation, also known as the Philadelphia chromosome, is a specific genetic abnormality that is strongly associated with Chronic Myeloid Leukemia (CML). This translocation leads to the fusion of the BCR and ABL genes, resulting in the creation of a constitutively active tyrosine kinase that drives the proliferation of malignant cells in CML.
While the other options are all types of leukemia, they are not as strongly associated with the t(9;22) translocation:
– Acute Lymphoblastic Leukemia (ALL) is more commonly associated with other genetic abnormalities, such as t(12;21) or t(1;19).
– Acute Myeloid Leukemia (AML) can have various genetic abnormalities, but t(9;22) is not as characteristic.
– Chronic Lymphocytic Leukemia (CLL) typically has different genetic features, such as deletions in chromosome 13q14 or trisomy 12.