Deficiency of factor VIII (antihaemophilic globulin)
A. Increases the bleeding time.
B. Is due to an abnormal gene on the Y chromosome.
C. To 75 per cent of its normal value results in excessive bleeding after tooth extraction.
D. Causes small (petechial) haemorrhages into the skin to cause purpura.
E. Affects the extrinsic, rather than the intrinsic, pathway for blood coagulation.
C. To 75 percent of its normal value results in excessive bleeding after tooth extraction.
Factor VIII deficiency is characteristic of hemophilia A, which affects the intrinsic pathway of the coagulation cascade and is associated with bleeding tendencies, particularly after trauma or surgical procedures. A deficiency of factor VIII often results in excessive bleeding even when levels are moderately reduced.