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Concerning vascular leakage with acute inflammation
A. endothelial cell contraction preferentially occurs in arterioles 20-60 µm in diameter.
B. tumour necrosis factor (TNF) affects leakage by direct endothelial cell necrosis.
C. immediate sustained response is due to widening of intercellular gaps.
D. chemically mediated endothelial contraction is usually reversible.
E. transcytosis is not thought to be a potential mechanism of increased permeability

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