A 25 years old girl is brought to the emergency department in the state of altered sensorium with high grade fever. Investigation revealed anemia, thrombocytopenia with fragmented red cells on peripheral blood smear examination. CT-brain is normal and a serum creatinine is 3.0 mg/dl. PT/APTT/TT are normal. Which of the following is the most effective treatment?
a. Plasma exchange therapy
b. Steriods with IVIg
c. Platelet transfusion
d. Broad–spectrum IV antibiotics