Which organism exerts its pathogenic effect by secretion of a potent exotoxin which continuously stimulates the adenyl cyclase activity of mucosal cells?
a. Clostridium welchii
b. Salmonella typhimurium
c. Shigella dysenteriae
d. Staphylococcus aureus
e. Vibrio cholerae
e) vibrio cholerae
It causes cholera by secreting a potent exotoxin known as cholera toxin. This toxin continuously stimulates adenyl cyclase activity in the mucosal cells of the intestine, leading to an increase in cyclic AMP (cAMP) levels. The elevated cAMP results in the secretion of large amounts of water and electrolytes into the intestinal lumen, causing the characteristic watery diarrhea associated with cholera
e. Vibrio cholerae**
Vibrio cholerae secretes cholera toxin, which continuously activates adenyl cyclase in intestinal mucosal cells, causing massive fluid loss and watery diarrhea.