The pathogenesis of cirrhosis involves all of the following EXCEPT:
A. demolition of collagen in the space of Disse
B. chronic inflammation
C. conversion of Kupffer cells into fibroblast-like cells
D. loss of fenestrations in sinusoidal capillaries
E. disruption of normal hepatic blood flow
Isha@2663 Answered question August 16, 2024
The pathogenesis of cirrhosis involves all of the following EXCEPT:
C. conversion of Kupffer cells into fibroblast-like cells
In cirrhosis, Kupffer cells, which are liver macrophages, do not typically convert into fibroblast-like cells. Instead, the key processes include:
- Chronic inflammation (B): Ongoing inflammation drives liver damage.
- Demolition of collagen in the space of Disse (A): This occurs as part of the fibrotic response.
- Loss of fenestrations in sinusoidal capillaries (D): This is part of the structural changes in the liver.
- Disruption of normal hepatic blood flow (E): Cirrhosis leads to altered blood flow due to fibrosis and nodular regeneration.
Isha@2663 Answered question August 16, 2024