Which of the following statements is not correct for local anesthetics?
a) In a tissue they exist either as an uncharged base or as a cation
b) A charged cationic form penetrates biologic membranes more readily than an uncharged form
c) Local anesthetics are much less effective in inflamed tissues
d) Low ph in inflamed tissues decreases the dissociation of nonionized molecules
instantknowledge Answered question August 16, 2024
B. A charged cationic form penetrates biologic membranes more readily than an uncharged form
This statement is incorrect. The uncharged form of local anesthetics penetrates biological membranes more readily than the charged cationic form. Once inside the cell, the cationic form becomes active and exerts its anesthetic effect.
instantknowledge Answered question August 16, 2024