Tolerance and drug resistance can be a consequence of:

The correct answer is:

a) Change in receptors, loss of them or exhaustion of mediators

Tolerance and drug resistance can occur due to changes in the target receptors, including:

– Downregulation or loss of receptors
– Desensitization or exhaustion of receptors
– Changes in receptor binding affinity or signaling pathways

a) Change in receptors, loss of them or exhaustion of mediators