Kallikrein.
A. directly converts C5 to C5a.
B. negatively inhibits activation of Hageman Factor.
C. has high molecular weigh kininogen as a precursor.
D. is inactivated by kininase.
E. all of the above.
E. all of the above.
Here’s a brief explanation for each point:
A. Directly converts C5 to C5a: True. Kallikrein can cleave C5 into C5a and C5b.
B. Negatively inhibits activation of Hageman Factor: True. Kallikrein has a role in the regulation of Hageman Factor (Factor XII) activation.
C. Has high molecular weight kininogen as a precursor: True. Kallikrein is involved in the conversion of high molecular weight kininogen to bradykinin.
D. Is inactivated by kininase: True. Kallikrein is inactivated by kininase, which degrades bradykinin and other kinins.