Metabolic transformation (phase 1) is:
a) Acetylation and methylation of substances
b) Transformation of substances due to oxidation, reduction or hydrolysis
c) Glucuronide formation
d) Binding to plasma proteins
aanya.bansal Answered question August 24, 2024
he correct answer is b) Transformation of substances due to oxidation, reduction, or hydrolysis.
Phase 1 of metabolic transformation, also known as functionalization, involves the conversion of lipophilic (fat-soluble) compounds into more polar (water-soluble) metabolites through various chemical reactions, including:
– Oxidation (e.g., cytochrome P450 enzymes)
– Reduction (e.g., azo reduction)
– Hydrolysis (e.g., esterases)
aanya.bansal Answered question August 24, 2024