The conversion of fibrinogen to fibrin
A. Is effected by prothrombin.
B. Involves the disruption of certain peptide linkages by a proteolytic enzyme.
C. Is followed by polymerization of fibrin monomers.
D. Is inhibited by heparin.
E. Is reversed by plasmin (fibrinolysin)
The correct answers are:
(B) Involves the disruption of certain peptide linkages by a proteolytic enzyme.
(C) Is followed by polymerization of fibrin monomers.
(D) Is inhibited by heparin.
(E) Is reversed by plasmin (fibrinolysin).
The conversion of fibrinogen to fibrin involves the enzyme thrombin, which cleaves peptide linkages in fibrinogen to form fibrin monomers. These monomers then polymerize to form a fibrin mesh. Heparin inhibits this process by preventing thrombin activity, and plasmin (fibrinolysin) can dissolve the fibrin clot after its formation.