HDL is synthesized and secreted from

The correct answer is (B) Liver.

HDL (High-Density Lipoprotein) is often referred to as “good cholesterol” because it helps remove excess cholesterol from the bloodstream and transport it to the liver for excretion. The liver plays a central role in HDL synthesis and secretion:

1. The liver produces apolipoprotein A-1 (apoA-1), the main protein component of HDL.
2. ApoA-1 is secreted into the bloodstream, where it binds to phospholipids and cholesterol, forming nascent HDL.
3. The liver also contributes to HDL maturation by adding additional lipids and proteins.