Which of the following statements about hypersensitivity reactions is FALSE:
A. type I hypersensitivity reactions rely on IgE antibodies
B. the Arthus reaction is a type III reaction
C. complement depletion usually results in type II reaction
D. T cells are fundamental to type IV reactions
E. type I reactions aid resistance to parasites
C. complement depletion usually results in type II reaction
Type II hypersensitivity reactions are mediated by antibodies (IgG or IgM) directed against cell surface or matrix antigens, often leading to complement activation and subsequent cell damage. Complement depletion does not usually result in type II reactions but can affect their severity.