A young lady presented with micro-angiopathic hemolytic anemia,thrombocytopenia and reduced level of consciousness. Her ADAMTS level was low and was diagnosed as TTP. She was given plasma exchange to which she responded and then relapses after 1 year.What is the treatment option now?
a. Plasma exchange
b. Plasma exchange plus rituximab
c. Plasma exchange plug splenectomy
d. High dose steroids
For a patient with relapsed TTP after one year, the best treatment option is:
b. Plasma exchange plus rituximab.
This combination targets the underlying autoimmune process more effectively than plasma exchange alone.