Which translocation is most commonly associated with acute promyelocytic leukemia (APL)?
A) t(8;14)
B) t(9;22)
C) t(15;17)
D) t(11;14)
aanya.bansal Answered question August 31, 2024
The correct answer is C) t(15;17).
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by the accumulation of abnormal promyelocytes in the bone marrow. The most common genetic abnormality associated with APL is the t(15;17) translocation, which involves the fusion of the promyelocytic leukemia (PML) gene on chromosome 15 with the retinoic acid receptor alpha (RARα) gene on chromosome 17.
aanya.bansal Answered question August 31, 2024