Which of the following is the hallmark of chronic myeloid leukemia (CML)?
A) Philadelphia chromosome
B) PML-RARA fusion gene
C) MYC gene amplification
D) Cyclin D1 overexpression
aanya.bansal Answered question August 31, 2024
The correct answer is A) Philadelphia chromosome.
The Philadelphia chromosome (Ph) is a specific chromosomal abnormality that is the hallmark of Chronic Myeloid Leukemia (CML). It is a result of a reciprocal translocation between chromosomes 9 and 22, denoted as t(9;22)(q34;q11). This translocation leads to the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL (Abelson) gene on chromosome 9, creating the BCR-ABL fusion gene.
aanya.bansal Answered question August 31, 2024