Pick out the right statement:
a) Microsomal oxidation always results in inactivation of a compound
b) Microsomal oxidation results in a decrease in compound toxicity
c) Microsomal oxidation results in an increase in ionization and water solubility of a drug
d) Microsomal oxidation results in an increase in lipid solubility of a drug thus its excretion from the organism is facilitated
The correct statement is (c) Microsomal oxidation results in an increase in ionization and water solubility of a drug.
Microsomal oxidation, also known as phase I metabolism, typically involves the addition of a functional group (-OH, -NH2, -SH) to the drug molecule, making it more polar and water-soluble. This increase in water solubility facilitates the excretion of the drug from the body.