A two year old black male is admitted to the hospital for his second episode of bacterial meningitis. His family history is positive for two other male siblings dying in infancy from sepsis. He also has a significant past medical history of recurrent ear infections and skin infections. What is the most likely diagnosis?
A. Factitious disorder by proxy
B. Severe combined immunodeficiency
C. DiGeorge Syndrome
D. Bruton’s Agammaglobulinemia
Given the recurrent bacterial infections, family history of similar issues, and the pattern of infections (ear infections, skin infections, and meningitis), the most likely diagnosis is:
D. Bruton’s Agammaglobulinemia
Bruton’s Agammaglobulinemia (X-linked agammaglobulinemia) is characterized by a deficiency of B cells and low levels of immunoglobulins, leading to increased susceptibility to bacterial infections. This condition typically presents in early childhood with recurrent bacterial infections.